Immunoglobulin genes: Inversion for gene construction

Bioinformatic Design and Construction of a Chimeric Gene Comprising the stxB, ctxB and blf1 Genes

Introduction bacteria species; Burkholderia pseudomallei, Vibrio cholera, and Shigella dysenteriae are the main pathogen causing  Melioidosis, Cholera, and Shigella in humans respectively. bacterial species have a protein that has antigenic prosperities along with being a mucus based adjuvant thus easing their delivery and immunogenicity. These proteins were BLF1(B. pseudomallei), CTxB (V. cho...

Jumping genes and the immunoglobulin V gene system.

Lyndon Array Construction during Burrows-Wheeler Inversion

In this paper we present an algorithm to compute the Lyndon array of a string T of length n as a byproduct of the inversion of the Burrows-Wheeler transform of T . Our algorithm runs in linear time using only a stack in addition to the data structures used for Burrows-Wheeler inversion. We compare our algorithm with two other linear-time algorithms for Lyndon array construction and show that co...

Evidence for gene conversion among immunoglobulin heavy chain variable region genes

We have previously reported that the VH region amino acid sequence of a phosphocholine (PC)-binding hybridoma antibody of CBA/J origin, HP101 6G6 (6G6), differs extensively from the VH regions of other PC-binding antibodies. The sequence of 6G6 VH appears to be derived from a gene homologous to the BALB/c V11 gene, a member of the PC VH (T15 VH) gene family not normally used to encode PC-bindin...

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes

IMGT/GENE-DB is the comprehensive IMGT genome database for immunoglobulin (IG) and T cell receptor (TR) genes from human and mouse, and, in development, from other vertebrates. IMGT/GENE-DB is the international reference for the IG and TR gene nomenclature and works in close collaboration with the HUGO Nomenclature Committee, Mouse Genome Database and genome committees for other species. IMGT/G...